Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof

US9475772B2 · kind B2 · utility

Assignee

• CRYSTAL PHARMA, S.A.U. · ES

Inventors

• Antonio Lorente Bonde-Larsen · Valladolid, ES
• Yolanda Fernández Sainz · Valladolid, ES
• Jesús Iglesias Retuerto · Valladolid, ES
• Javier Gallo Nieto · Valladolid, ES

Key dates

• Filing date: Sep 9, 2013
• Grant date: Oct 25, 2016
• Expiry date: Sep 9, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield.