Substituted benzothienyl-pyrrolotriazines and uses thereof

US9475815B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Mario Lobell · Wuppertal, DE
• Walter Hubsch · Wuppertal, DE
• Hartmut Schirok · Wuppertal, DE
• Melanie HEROULT · Mülheim an der Ruhr, DE
• Dirk Brohm · Mettmann, DE
• Marie-Pierre Collin · Wuppertal, DE
• Sylvia Grünewald · Berlin, DE
• Klemens Lustig · Wuppertal, DE
• Ulf Bömer · Glienicke, DE
• Verena Voehringer · Wolfegg, DE
• Niels Lindner · Wuppertal, DE

Key dates

• Filing date: Feb 20, 2013
• Grant date: Oct 25, 2016
• Expiry date: Feb 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.