Substituted-1,4-dihydropyrazolo[4,3-b]indoles

US9475816B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Zacharia Cheruvallath · San Diego, US
• Mallareddy Komandla · San Diego, US
• John David Lawson · San Diego, US
• Christopher McBride · Oakland, US
• Mingnam Tang · San Diego, US

Key dates

• Filing date: Sep 6, 2013
• Grant date: Oct 25, 2016
• Expiry date: Oct 6, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula 1,and pharmaceutically acceptable salts thereof, wherein L, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.