RNA-interference by single-stranded RNA molecules

US9476044B2 · kind B2 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Thomas Tuschl · Oettingen, DE
• Javier Martinez · Madrid, ES
• Agnieszka Patkaniowska · New York, US
• Henning Urlaub · Oettingen, DE
• Reinhard Luehrmann · Marburg, DE

Key dates

• Filing date: Jul 22, 2014
• Grant date: Oct 25, 2016
• Expiry date: Jul 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2330/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.