Modification of RNA, producing an increased transcript stability and translation efficiency

US9476055B2 · kind B2 · utility

Assignee

• BioNTech AG · DE

Inventors

• Ugur Sahin · Mainz, DE
• Silke Holtkamp · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Sebastian Kreiter · Mainz, DE

Key dates

• Filing date: Sep 28, 2006
• Grant date: Oct 25, 2016
• Expiry date: Jan 9, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.