Diblock copolymers and polynucleotide complexes thereof for delivery into cells
US9476063B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 13, 2009 |
| Grant date | Oct 25, 2016 |
| Priority date | — |
| Expiry date | Oct 13, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.