Digital microfluidic devices and methods incorporating a solid phase

US9476811B2 · kind B2 · utility

Assignee

• The Governing Council of the University of Toronto · CA

Inventors

• Jared M. Mudrik · Thornhill, CA
• Hao Yang · Vancouver, CA
• Aaron R. Wheeler · Toronto, CA

Key dates

• Filing date: Oct 3, 2011
• Grant date: Oct 25, 2016
• Expiry date: Oct 18, 2033

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0427
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Devices and methods are provided for performing droplet-based solid phase processing steps on a digital microfluidic device. A solid phase material, which may be a porous solid phase material such as a porous polymer monolith is formed or located on a digital microfluidic element. The solid phase may be formed by an in-situ method in which the digital microfluidic array is actuated to transport a droplet of solid phase pre-cursor solution to a selected element on the array, and subsequently processed to form a solid phase on the array element. The integration of a solid phase material with a digital microfluidic array enables a wide range of applications including solid phase extraction and sample concentration.