Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
US9480653B2 · kind B2 · utility
9Cited by
3References
8Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 20, 2015 |
| Grant date | Nov 1, 2016 |
| Priority date | — |
| Expiry date | Feb 20, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.