Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof
US9480667B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 2011 |
| Grant date | Nov 1, 2016 |
| Priority date | — |
| Expiry date | Jan 19, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.