Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale
US9480715B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jan 10, 2014 |
| Grant date | Nov 1, 2016 |
| Priority date | — |
| Expiry date | Mar 25, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25− T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4highCD25+Foxp3+ regulatory T cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.