Disubstituted maleic anhydrides with altered kinetics of ring closure
US9481661B2 · kind B2 · utility
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Key dates
| Filing date | May 31, 2012 |
| Grant date | Nov 1, 2016 |
| Priority date | — |
| Expiry date | Aug 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.