Methods for increasing mannose content of recombinant proteins
US9481901B2 · kind B2 · utility
4Cited by
18References
15Claims
0Family size
Inventors
Key dates
| Filing date | May 29, 2014 |
| Grant date | Nov 1, 2016 |
| Priority date | — |
| Expiry date | May 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2500/34
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.