Patent · US Active

Protective HDL particle number evaluations

US9483611B2 · kind B2 · utility

2Cited by
8References
18Claims
0Family size

Assignee

Inventors

Key dates

Filing dateApr 26, 2013
Grant dateNov 1, 2016
Priority date—
Expiry dateOct 1, 2034

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2800/50
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Embodiments of the invention are directed to improved discrimination of protective (anti-atherogenic) HDL from atherogenic or non-protective (NP) HDL. The methods, systems and computer program products determine protective high density lipoprotein particle (HDL-P) numbers. The methods include obtaining concentration measurements of at least twenty subpopulations of HDL-P subclasses in a blood plasma or serum sample and calculating a protective HDL-P number using (i) a defined subset of the obtained HDL-P concentration measurements or (ii) a zero or defined weighting factor below 1 for HDL-P concentration measurements for HDL subclasses associated with particle sizes above about 11 nm.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.