Pro-coagulant compounds and methods of use thereof
US9486507B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 9, 2012 |
| Grant date | Nov 8, 2016 |
| Priority date | — |
| Expiry date | Jun 9, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides pro-coagulant compounds (e.g., pro-coagulant peptides or peptide derivatives) and methods of using and making those compounds. The present disclosure further provides conjugates between a pro-coagulant compound of the present disclosure (e.g., pro-coagulant peptide or peptide derivative) and a polypeptide selected from FIX, FVIIa, FVIII, and platelet targeting moieties (e.g., PDG-13), wherein the compound is linked to the polypeptide optionally via a linker. The compounds and conjugates of the present disclosure are useful for the treatment of coagulation disorders, such as hemophilia A and hemophilia B. The present disclosure further provides methods of using and making the conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.