Esterified cellulose ethers of low viscosity

US9486532B2 · kind B2 · utility

Assignee

• DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

• Meinolf Brackhagen · Walsrode, DE
• Steven J. Guillaudeu · Midland, US
• Nicholas S. Grasman · Midland, US
• Oliver Petermann · Hamburg, DE
• Robert L. Schmitt · Stuart, US
• Matthias Sprehe · Walsrode, DE

Key dates

• Filing date: Feb 28, 2014
• Grant date: Nov 8, 2016
• Expiry date: Mar 5, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B13/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.