Patent · US Active

Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions

US9487478B2 · kind B2 · utility

4Cited by

16References

21Claims

0Family size

Assignee

CAYMAN CHEMICAL COMPANY, INC. · US

Inventors

Stephen Douglas Barrett · Hartland, US
Fred Lawrence Ciske · Dexter, US
Joseph Michael Colombo · Ann Arbor, US
Gregory William Endres · Saline, US
Bradlee David Germain · Ann Arbor, US
Andriy Kornilov · Ypsilanti, US
James Bernard Kramer · Sylvania, US
Adam Uzieblo · Farmington Hills, US
Kirk M. Maxey · Ann Arbor, US

Key dates

Filing date	Oct 1, 2015
Grant date	Nov 8, 2016
Priority date	—
Expiry date	Oct 1, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61L2430/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are compounds of formula (I)and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.