Process for preparation of montelukast sodium

US9487487B2 · kind B2 · utility

Assignee

• LAURUS LABS LIMITED · IN

Inventors

• Srinivas Simhadri · Secunderabad, IN
• Yaseen Mohammad · Hyderabad, IN
• Venkata Sunil Kumar Indukuri · Hyderabad, IN
• Seeta Ramanjaneyulu Gorantla · Hyderabad, IN
• Satyanarayana Chava · Hyderabad, IN

Key dates

• Filing date: May 17, 2013
• Grant date: Nov 8, 2016
• Expiry date: May 17, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a process for the preparation of montelukast sodium. The process comprises a) reacting 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol with methane sulfonyl chloride and coupling the resultant mesylate compound with 1-(mercaptomethyl)cyclopropane acetic acid in presence of a base and free alkali source followed by saltification with an amine in a single step reaction and b) converting the montelukast amine salt to montelukast sodium salt.