Stabilized polypeptides as regulators of RAB GTPase function
US9487562B2 · kind B2 · utility
14Cited by
47References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2012 |
| Grant date | Nov 8, 2016 |
| Priority date | — |
| Expiry date | Jun 15, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides inventive polypeptides comprising a C terminal RAB binding domain (RabBD) of RAB family interacting proteins (FIPs) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating RAB function comprising contacting an inventive stapled polypeptide with a RAB protein, and methods of treatment associated with modulation of RAB activity. The present invention also provides methods of making the inventive stapled polypeptides by ring closing metathesis of unstapled polypeptide precursors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.