Patent · US Active

Activatable antibodies that bind interleukin-6 receptor and methods of use thereof

US9487590B2 · kind B2 · utility

12Cited by

5References

35Claims

0Family size

Assignee

CytomX Therapeutics, Inc. · US

Inventors

James William West · Lompoc, US
Jason Gary Sagert · Lompoc, US
Daniel Robert Hostetter · Palo Alto, US
Stephen Moore · Las Vegas, US
Margaret Thy Luu Nguyen · San Francisco, US
Olga Vasiljeva · Cupertino, US
Jeanne Grace Flandez · Oakland, US

Key dates

Filing date	Sep 25, 2013
Grant date	Nov 8, 2016
Priority date	—
Expiry date	Apr 7, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/50
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to interleukin-6 receptor (IL-6R), and to methods of making and using these anti-IL-6R activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.