Oligonucleotide modulators of the toll-like receptor pathway
US9487778B2 · kind B2 · utility
1Cited by
24References
16Claims
0Family size
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Key dates
| Filing date | Mar 1, 2012 |
| Grant date | Nov 8, 2016 |
| Priority date | — |
| Expiry date | Aug 16, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/321
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of a Toll like receptor genes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.