Biomarkers of osteoarthritis

US9488646B2 · kind B2 · utility

Assignee

• The Curators of the University of Missouri · US

Inventors

• James L. Cook · Columbia, US
• Cristi R. Cook · Columbia, US
• Aaron Stoker · Columbia, US
• Keiichi Kuroki · Columbia, US
• Bridget Colleen Garner · Athens, US
• Richard Evans · Loughborough, GB
• Brandon L. Roller · Naples, US
• Prakash Sidha Jayabalan · Columbia, US

Key dates

• Filing date: Feb 7, 2014
• Grant date: Nov 8, 2016
• Expiry date: Feb 7, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.