Model and methods for identifying points of action in electrically active cells
US9489474B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 7, 2011 |
| Grant date | Nov 8, 2016 |
| Priority date | — |
| Expiry date | Jun 18, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B5/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.