Parathyroid hormone analogs and uses thereof

US9492508B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• CHUGAI SEIYAKU KABUSHIKI KAISHA · JP

Inventors

• Thomas J. Gardella · Needham, US
• John T. Potts, Jr. · Newton, US
• Harald Jueppner · Cambridge, US
• Makoto Okazaki · Kawagoe, JP

Key dates

• Filing date: May 12, 2011
• Grant date: Nov 15, 2016
• Expiry date: May 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/635
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed.