Influenza virus-like particles (VLPS) comprising hemagglutinin
US9492528B2 · kind B2 · utility
5Cited by
11References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 2, 2009 |
| Grant date | Nov 15, 2016 |
| Priority date | — |
| Expiry date | Dec 19, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06F2209/508
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.