Preparation of extracellular matrix-modified tissue engineered nerve grafts for peripheral nerve injury repair

US9492589B2 · kind B2 · utility

Assignee

• Nanjing University · CN

Inventors

• Xiaosong GU · 安丰镇, CN
• Fei Ding · Thalwil, CH
• Yun Gu · Beijing, CN
• Chengbin Xue · 安丰镇, CN
• Yumin Yang · 安丰镇, CN
• Yongjun Wang · Pleasanton, US
• Leilei GONG · 安丰镇, CN

Key dates

• Filing date: May 27, 2013
• Grant date: Nov 15, 2016
• Expiry date: May 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2527/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.