Compositions and methods for the delivery of nitric oxide

US9493527B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Stephen P. L. Cary · San Mateo, US
• Elizabeth M. Boon · Stony Brook, US
• Jonathan A. Winger · Oakland, US
• Michael A. Marletta · Berkeley, US

Key dates

• Filing date: Sep 18, 2014
• Grant date: Nov 15, 2016
• Expiry date: Sep 18, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/102499
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.