Methods and devices for detecting structural changes in a molecule measuring electrochemical impedance
US9494583B2 · kind B2 · utility
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1References
13Claims
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Key dates
| Filing date | Sep 28, 2012 |
| Grant date | Nov 15, 2016 |
| Priority date | — |
| Expiry date | Sep 28, 2032 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00725
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The disclosure relates to a method of detecting a structural change in a molecule that is attached to a surface that is electrically conductive, wherein the method includes monitoring the phase of the electrochemical impedance at the surface, and wherein a change in the phase indicates a change in the structure of the molecule. The disclosure also relates to arrays and methods for making arrays having molecules, such as polypeptides, attached to electrically conductive surfaces, such as electrodes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.