Mutations of histone proteins associated with proliferative disorders

US9494591B2 · kind B2 · utility

Assignees

• The Royal Institution for the Advancement of Learning/McGill University · CA
• UNIVERSITÄTSKLINIKUM HEIDELBERG · DE
• GERMAN CANCER RESEARCH CENTER (DKFZ) · DE

Inventors

• Nada Jabado · Montréal, CA
• Stefan M. Pfister · Heidelberg, DE
• Christoph Plass · Schriesheim, DE
• Andrey Korshunov · Heidelberg, DE
• Hendrik Witt · Heidelberg, DE
• Dominik Sturm · Heidelberg, DE
• David Jones · Milford, US
• Peter Lichter · Heidelberg, DE
• Elke Pfaff · Heidelberg, DE

Key dates

• Filing date: Nov 21, 2012
• Grant date: Nov 15, 2016
• Expiry date: Dec 11, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship.