Translocation of non-natural chemical entities through anthrax protective antigen pore

US9498538B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US

Inventors

• Xiaoli Liao · Longbeilingcun, CN
• Amy E. Rabideau · Waltham, US
• Bradley L. Pentelute · Cambridge, US
• Jingjing Ling · Cambridge, US
• Gizem Akçay · Medford, US
• John R. Collier · Baton Rouge, US

Key dates

• Filing date: May 21, 2013
• Grant date: Nov 22, 2016
• Expiry date: Aug 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P21/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.