Compartmentalized screening by microfluidic control
US9498759B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 12, 2005 |
| Grant date | Nov 22, 2016 |
| Priority date | — |
| Expiry date | Apr 6, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.