Opsin-binding ligands, compositions and methods of use
US9499464B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Oct 19, 2012 |
| Grant date | Nov 22, 2016 |
| Priority date | — |
| Expiry date | Oct 19, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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