Inhibitors of cellular necrosis and related methods

US9499521B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• Shanghai Institute of Organic Chemistry · CN

Inventors

• Junying Yuan · Newton, US
• Yijun Zhou · Lund, SE
• Shan Qian · Shanghai, CN
• Dawei Ma · Shanghai, CN

Key dates

• Filing date: Jun 27, 2016
• Grant date: Nov 22, 2016
• Expiry date: Jun 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/78
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound having the following structure (I):or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided.