Antibacterial antisense oligonucleotide and method
US9499583B2 · kind B2 · utility
3Cited by
66References
2Claims
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Key dates
| Filing date | Dec 21, 2015 |
| Grant date | Nov 22, 2016 |
| Priority date | — |
| Expiry date | Dec 21, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.