CyaA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses
US9499809B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Jul 23, 2013 |
| Grant date | Nov 22, 2016 |
| Priority date | — |
| Expiry date | Jul 23, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a chimeric protein comprising or consisting of, from N-terminal to C-terminal, (a) a N-terminal part of a Bordetella CyaA protein (b) a heterologous polypeptide, and (c) a C-terminal part of a Bordetella CyaA protein. The invention also relates to a polynucleotide encoding a deleted version of a Bordetella CyaA, as well as a polynucleotide encoding this chimeric protein. A composition comprising at least one chimeric protein(s) of the invention and the prophylactic and/or therapeutic uses of said composition are also part of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.