Synthesis and use of kinase inhibitors
US9505719B2 · kind B2 · utility
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31Claims
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Key dates
| Filing date | Aug 7, 2013 |
| Grant date | Nov 29, 2016 |
| Priority date | — |
| Expiry date | Aug 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.