Inhibitors of D-amino acid oxidase
US9505753B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Aug 8, 2013 |
| Grant date | Nov 29, 2016 |
| Priority date | — |
| Expiry date | Aug 8, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
D-amino acid oxidase (DAAO) inhibitors and methods of their use, either alone or in combination with D-serine or D-alanine, to facilitate allosteric activation of NMDA receptor-mediated neurotransmission and methods of their use as therapeutic agents for treating a subject afflicted with one or more cognitive-disorders, such as schizophrenia, including subjects suffering from negative symptoms and cognitive impairments, post-traumatic stress disorder (PTSD), or pain, are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.