Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof

US9505782B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Jolanta Grembecka · Ann Arbor, US
• Tomasz Cierpicki · Ann Arbor, US
• Dmitry Borkin · Ann Arbor, US
• Jay Hess · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• Xiaoqin Li · Ann Arbor, US

Key dates

• Filing date: Nov 10, 2015
• Grant date: Nov 29, 2016
• Expiry date: Nov 10, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 2:and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.