Patent · US Active

Multi-component inhibitors of nucleic acid polymerases

US9505846B2 · kind B2 · utility

0Cited by
28References
11Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 28, 2005
Grant dateNov 29, 2016
Priority date—
Expiry dateNov 20, 2027

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/76
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially inhibit its polymerase activity. Another component is a molecule or complex of molecules that binds to a PBM (i.e., a PBM-binding molecule). The combination of the PBM and PBM-binding molecule/complex substantially inhibits polymerase activity. The disclosed multi-component inhibitors are useful for DNA sequencing, nucleic acid amplification, cloning and synthesis, and the like.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.