Patent · US Active

Engineered heterodimeric protein domains

US9505848B2 · kind B2 · utility

37Cited by

9References

7Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Jonathan Davis · Waltham, US
James S. Huston · Newton, US

Key dates

Filing date	Oct 3, 2014
Grant date	Nov 29, 2016
Priority date	—
Expiry date	Oct 3, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. Methods of designing and using the engineered proteins are also included.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.