Antibody constructs for influenza M2 and CD3

US9505849B2 · kind B2 · utility

Assignees

• AMGEN RESEARCH (MUNICH) GMBH · DE
• VIB VZW · BE
• UNIVERSITEIT GENT · BE

Inventors

• Peter Kufer · Munich, DE
• Tobias Raum · Munich, DE
• Markus Muenz · Lenggries, DE
• Jochen Pendzialek · Munich, DE
• Walter Fiers · Laarne, BE
• Xavier Saelens · Ieper, BE
• Kenny ROOSE · Ettelgem, BE

Key dates

• Filing date: Mar 17, 2014
• Grant date: Nov 29, 2016
• Expiry date: Mar 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.