Microbubble devices, methods and systems

US9506027B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Mark A. Borden · Boulder, US
• Eric Lima · New York, US
• Clark T. Hung · Ardsley, US
• Shashank Ramesh Sirsi · New York, US

Key dates

• Filing date: Nov 22, 2013
• Grant date: Nov 29, 2016
• Expiry date: Dec 4, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/76
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.