Amino lipids, their synthesis and uses thereof

US9511024B2 · kind B2 · utility

Assignee

• INCELLA GMBH · DE

Inventors

• Gary Davidson · DeSoto, US
• Pavel Levkin · Blankenloch, DE
• Linxian Li · Beijing, CN
• Yi Su · Blankenloch, DE
• David Zahner · New York, US

Key dates

• Filing date: May 15, 2012
• Grant date: Dec 6, 2016
• Expiry date: Jan 12, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides new amino lipids and a convenient method for synthesizing these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.