Synthesis of acridinium compounds by N-alkylation of acridans
US9512080B2 · kind B2 · utility
1Cited by
5References
27Claims
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Key dates
| Filing date | Jul 10, 2013 |
| Grant date | Dec 6, 2016 |
| Priority date | — |
| Expiry date | Jul 10, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D219/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.