Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
US9512092B2 · kind B2 · utility
1Cited by
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20Claims
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Key dates
| Filing date | Dec 11, 2014 |
| Grant date | Dec 6, 2016 |
| Priority date | — |
| Expiry date | Dec 11, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7009
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.