Fibronectin cradle molecules and libraries thereof
US9512199B2 · kind B2 · utility
3Cited by
2References
5Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Aug 1, 2011 |
| Grant date | Dec 6, 2016 |
| Priority date | — |
| Expiry date | Aug 21, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2318/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII) (e.g., FnIII7, FnIII10 and FnIII14) together with the surface exposed residues of the beta-sheet. The invention also pertains to a method of forming a library of FnIII domain polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.