Patent · US Active

In vitro model for neuronal death

US9512399B2 · kind B2 · utility

1Cited by
1References
13Claims
0Family size

Inventor

Key dates

Filing dateOct 3, 2014
Grant dateDec 6, 2016
Priority date—
Expiry dateOct 3, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2503/02
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention demonstrates the formation of a novel polarized membrane lipid raft signaling module in neurons, in response to several diverse neurotoxic stimuli. This polarization occurs well before neurons commit to die, and is an early mechanism in death signaling. The formation of this signaling module is dependent on cholesterol for its formation and provides a mechanistic explanation for the protective effects of cholesterol depleting drugs in several non-neural models of cell death. As such, the formation of the signaling module lends itself as a novel screen for the identification of new drugs and therapeutics which would retard its formation and protect against neuronal injury and death.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.