Patent · US Active

Methods, compositions, and kits for detecting allelic variants

US9512473B2 · kind B2 · utility

6Cited by
43References
21Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 28, 2014
Grant dateDec 6, 2016
Priority date—
Expiry dateNov 7, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/156
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.