Digital holographic method of measuring cellular activity and measuring apparatus with improved stability
US9514271B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 17, 2011 |
| Grant date | Dec 6, 2016 |
| Priority date | — |
| Expiry date | Nov 1, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG03H2222/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, which should not be confused with mechanical motion of the system. Apparatus for motility contrast imaging that provides increased mechanical stability is disclosed. It is based on common-path configurations, in which the signal and reference beams share optical elements in their paths to the detector. The two beams share mechanical motions in common, and hence these motions do not contribute to the signal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.