Methods to treat neurodegenerative diseases
US9517223B2 · kind B2 · utility
1Cited by
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17Claims
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Key dates
| Filing date | Aug 6, 2013 |
| Grant date | Dec 13, 2016 |
| Priority date | — |
| Expiry date | Aug 6, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the discovery that motor neurons derived from patients with a neurodegenerative disease have decreased delayed rectifier potassium current and increased persistent sodium current compared to motor neurons derived from control healthy individuals. The present invention is also based on the discovery that the class of compounds known as “potassium channel openers” can be used to treat neurodegenerative diseases, including ALS, Parkinson's disease, Alzheimer's disease, epilepsy, and pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.