Temperature dependent activation of catalytic nucleic acids for controlled active substance release

US9517272B2 · kind B2 · utility

Assignee

• MAGFORCE AG · DE

Inventors

• Jiang Gao · Berlin, DE
• Monika Fischler · Berlin, DE
• Volker Erdmann · Berlin, DE

Key dates

• Filing date: Dec 16, 2010
• Grant date: Dec 13, 2016
• Expiry date: Feb 23, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an active substance release system containing two compounds. The first compound comprises a nanoparticle, combined with an oligonucleotide inhibition strand that is hybridized with a catalytically active nucleic acid. The second compound comprises a carrier, combined with a substrate molecule that is coupled to a therapeutic active substance. By means of external stimulation, the catalytically active nucleic acid of the first compound is released and specifically binds to the substrate molecule of the second compound. This leads to cleavage of the substrate molecule, whereby the active substance bound thereto is released.